|
KMID : 0617319930030010048
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
1993 Volume.3 No. 1 p.48 ~ p.62
|
|
|
Drug Release from Hollow Type Suppository(Ⅱ)
|
|
|
|
|
Abstract
|
|
|
In order to evaluate an Indomethacin(IDM) Polyvinyl alcohol(PVA) Hydogel as a sustained-release vehicle for rectal administration, the in vitro release characteristics of IDM from hydrogel were examined. The 5 types of hollow type suppositories and one type of conventional suppository were prepared with PVA hydrogel gy a low-temperature crystallization method.
Slower release of IDM occurred at the higher PVA concentration and the amount o f the cross-linking agent of a glutaraldehyde(GA). The drug amount released(%) from type V, hollow type suppository containing 12.5mg of IDM powder dispersed in the vase and 0.5ml of 6.25%(w/v) IDM-PEG 300 solution in the cavity, was high as about 95% and the release rates were more rapid at early time than any other suppositories.
For comparative study, IDM suppository was prepared with Witepsol H-15 using the fusion method. Amounts of IDM released form hydrogel showed a sustained released compared with Witepsol H-15 suppository.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|